Brugada Syndrome: A Silent Threat to the Heart. What is Brugada Syndrome? A potentially fatal genetic disorder affecting the heart's electrical system, leading to an increased risk of sudden cardiac death--especially during sleep. It is caused by mutations in the SCN5A gene, affecting sodium channel function and cardiac conduction. Brugada Pattern vs. Brugada Syndrome G Brugada Pattern: ⁃ An incidental ECG finding without symptoms, ⁃ Can be triggered by fever, medications, or electrolyte imbalan