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17:47
YouTube
Dr. Jack Auty
Apoptosis Explained: p53 Activation, Cytochrome c Release, the Apoptosome, and the Caspase Cascade
This video walks through the molecular sequence that drives apoptosis (programmed cell death), starting with the key regulator p53. Under normal conditions, p53 is continuously produced but kept low because it is ubiquitinated and degraded by the proteasome. When a cell receives stress signals, either intrinsic (for example DNA damage) or ...
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