Trough levels should be obtained within 30 minutes before the next scheduled dose. Weekly vancomycin levels should be obtained for long-term vancomycin use with stable renal function.

A concise guide to interpreting vancomycin trough levels, timing the draw, and adjusting the dose safely especially in renal dysfunction.

In adults with normal renal function, the half-life of vancomycin is 6 to 12 hours. 2 If steady state occurs within five half-lives (that is, in 30 to 60 hours), a vancomycin trough before the fourth dose is …

Sep 29, 2025 · Vancomycin is a glycopeptide antibiotic administered intravenously for treatment of patients with suspected or proven invasive gram-positive infections, including methicillin-resistant …

Feb 22, 2023 · Do not restart vancomycin until the random/trough level is estimated or confirmed to be at/near 10-20 mg/dl. Allow sufficient time for drug clearance before restarting next dose.

Selecting and interpreting trough levels: Always interpret trough level in context of timing of the preceding dose, particularly if the level appears to be much higher or lower than expected Trough for …

Aug 21, 2025 · A “trough level” refers to the lowest concentration of a medication in a patient’s bloodstream, measured just before the next dose is due. For vancomycin, this measurement typically …

Recent guidelines have recommended target trough serum vancomycin concentra-tions of 15–20 mg/L.41 However, the safety of higher trough vancomycin concentrations over a prolonged period …

Vancomycin trough concentrations between 15 and 20 mg/L are no longer recommended due to increased risk of acute kidney injury (AKI) and lack of clinical benefit

Nov 18, 2019 · Vancomycin is an antibiotic drug used to treat serious, life-threatening infections by gram-positive bacteria that are resistant to less-toxic agents. The reference range for vancomycin …