EMBO Press1d
Multi-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures
Multi-epitope immunopurifications of huntingtin (HTT) from vulnerable brain regions of Huntington’s disease (HD) models ...
EMBO Press2d
Mouse promoters are characterised by low occupancy and high turnover of RNA polymerase II
Single-Molecule Footprinting reveals that RNA polymerase II (Pol II) occupancy is infrequent at mouse promoters. This results ...
EMBO Press6d
TFE3 fusions drive oxidative metabolism and ferroptosis resistance in translocation renal cell carcinoma
TFE3 fusion proteins are the oncogenic drivers of translocation renal cell carcinoma but their mechanism of action remains ...
EMBO Press9d
PARP7 as a new target for activating anti-tumor immunity in cancer
PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...
EMBO Press7d
Beyond mitotic arrest: the diverse effects of microtubule-targeting drugs on tumor vasculature
For decades microtubule-targeting agents (MTAs) have been a cornerstone of cancer treatment regimens and continue to be heavily employed as backbone chemotherapy in combination with new targeted ...
EMBO Press13d
A new hybrid post-translational modification—have you lost your (MARUb)les?
Recent work in The EMBO Journal describes a new hybrid post-translational modification of proteins, composed of a poly-ubiquitin chain that is attached to a target protein via a mono-ADP-ribose (MAR) ...
The EMBO Journal2d
SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Metastasis is the primary cause of death in ...
The EMBO Journal9d
Molecular architecture of glideosome and nuclear F-actin in Plasmodium falciparum
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Actin-based motility is required for the ...
The EMBO Journal2d
HAND1 level controls the specification of multipotent cardiac and extraembryonic progenitors from human pluripotent stem cells
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Diverse sets of progenitors contribute to the ...
The EMBO Journal2d
Liver TET1 promotes metabolic dysfunction-associated steatotic liver disease
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Global hepatic DNA methylation change has been ...