A subset of cells in the brain coordinate bladder muscle and sphincter function to precisely control urination, according to new research.

This variability may be part of a bet-hedging strategy, where populations express a range of phenotypes to ensure survival in unpredictable environments. In addition phenotypic variability between ...

Department of Neurobiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, USA ...

This study provides valuable insights into the differential impact of intrinsic and synaptic conductances on circuit robustness, emphasizing intrinsic plasticity as a crucial but often overlooked ...

The function of human airway macrophages can be therapeutically manipulated by targeting cellular metabolism to support immunity in the lung, aiding the design of innovative strategies in respiratory ...

This work presents a valuable exploration of AI-assisted protein engineering, particularly in designing a VHH antibody with enhanced resistance and stability to extreme environments. However, the ...

Department of Microbiolog, Immunology, and Biochemistry. University of Tennessee Health Science Center, Memphis, USA ...

This study provides valuable evidence for the mechanism underlying KCNC1-related developmental and epileptic encephalopathy. The authors have generated and characterized a new knock-in mouse with a ...

This valuable study proposes a novel rapid-entry mechanism of S. aureus that involves the rapid release of calcium from lysosomes. The strength of the paper lies in a very interesting hypothesis; what ...

This manuscript describes a novel magnetic steering technique to target human adipose derived mesenchymal stem cells (hAMSC) or induce pluripotent stem cells to the TM (iPSC-TM). The authors ...

Experimental schematic and design. A) Schematic of magnetically-steered cell delivery to the TM. As cells are injected into the anterior chamber at a low flow rate, the experimenter places the “point ...

Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. This manuscript describes a novel magnetic steering technique ...