Objectives Bone remodelling is a highly dynamic process dependent on the precise coordination of osteoblasts and haematopoietic-cell derived osteoclasts. Changes in core metabolic pathways during ...

Objectives To report the level and trends of prevalence, incidence and years lived with disability (YLDs) for osteoarthritis (OA) in 195 countries and territories from 1990 to 2017 by age, sex and ...

Objectives To provide an update of the EULAR rheumatoid arthritis (RA) management recommendations addressing the most recent developments in the field. Methods An international task force was formed ...

Objective To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of ...

Correspondence to Professor Shiquan Sun, Xi'an Jiaotong University, Xi'an, Shaanxi, China; sqsunsph{at}xjtu.edu.cn; Professor Guangdun Peng, Chinese Academy of Sciences, Guangzhou, Guangdong, China; ...

Background The optimal first-line treatment in early rheumatoid arthritis (RA) is debated. We compared clinical and radiographic outcomes of active conventional therapy with each of three biological ...

1 Columbia University Irving Medical Center, Rheumatology, New York, United States of America 2 Vanderbuilt University Medical Center, Medicine, Nashville, United States of America 3 University of ...

Background An increased risk of malignancy was reported in patients with Systemic Lupus Erythematosus (SLE) [1-3]. Objectives To estimate the prevalence of cancer in a Portuguese cohort of patients ...

5 CNRS, INSERM, Institut Necker Enfants Malades-INEM, F-75015 Paris, France; Faculté de Médecine, University of Paris City, Paris, France Objectives Alterations in tryptophan (Trp) metabolism have ...

2 Clinical Development, Antares Pharma Inc, Ewing, New Jersey, USA 3 Medical Department, Antares Pharma Inc, Ewing, New Jersey, USA Objective To compare the relative bioavailability, safety and ...

Correspondence to Dr Rishi J Desai, Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital, Boston, Massachusetts, USA; RDESAI{at}BWH.HARVARD.EDU Objectives Recent ...

Chimeric antigen receptors (CARs) are synthetic proteins designed to direct an immune response toward a specific target and have been used in immunotherapeutic applications through the adoptive ...