Kickoff from Stade Louis II in Monaco is set for 3 p.m. ET. The latest Monaco vs. Manchester City odds list the visitors as the -235 favorites (risk $215 to win $100) on the 90-minute money line, with Monaco listed as the +550 underdogs.

Top teams like Barcelona, Real Madrid, Manchester City, Chelsea, Liverpool , and many others will clash across 2025/26 to crown one European champion for the season. Last season's title winners Paris Saint-Germain will, for the first time in club history, look to defend their status as continental kings.

Real Madrid faces Juventus in the UEFA Champions League on Wednesday, Oct. 22, 2025 (10/22/25) at Bernabéu in Madrid, Spain.