The San Francisco 49ers' visit to Buffalo could be more painful than expected for Kyle Shanahan following the loss to the ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

Christian McCaffrey’s injury threatens to sideline the 49ers’ star running back for the rest of the season. The team’s ...

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A ...

The 49ers’ third straight defeat came in 35-10 fashion to the AFC East-clinching Buffalo Bills amid a snowstorm at Highmark ...

The swagger is officially gone from this season's 49ers after another miserable outing in a 35-10 loss in Buffalo.

The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.

The 49ers season is still trending down and now they're searching for answers on if they can get back on track.

The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...

What’s wrong with the defending NFC champions? San Francisco 49ers head coach Kyle Shanahan has been asked variations of that question multiple times during a disappointing season, but he offered his ...

San Francisco 49ers running back Christian McCaffrey could be done for the season after just four games. As head coach Kyle ...

Buffalo was a perfect 4-for-4 in the red zone. A big factor in the Bills' success was their run game. RB James Cook had 14 ...