49ers head coach Kyle Shanahan told reporters Monday that McCaffrey suffered a posterior cruciate ligament (PCL) injury during Sunday's 35-10 loss to the Buffalo Bills, and will be placed on injured reserve as result. McCaffrey's recovery is expected to be six weeks, meaning that the rest of his season is in jeopardy.

The San Francisco 49ers on Tuesday announced how they’d replace running back Christian McCaffrey. In a slew of roster moves the 49ers placed McCaffrey on IR, claimed RB Israel Abanikanda off waivers from the New York Jets and signed wide receiver Ronnie Bell to the practice squad.