The NFL is hard on quarterbacks. As the season goes on, the number of QBs who start every game gets smaller and smaller. Here ...

There are plenty of teams still in contention for playoff spots, and teams on the bubble will have to start their postseason ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

Being without Brock Purdy against the Green Bay Packers stung the San Francisco 49ers. It essentially chalked up the game as a loss for the 49ers before they ev ...

San Francisco 49ers defensive end Nick Bosa (hip/oblique) was pulled from his team's Week 11 loss to the Seattle Seahawks due ...

Buffalo Bills look to extend its six-game win streak as Josh Allen faces an unfamiliar foe in the San Francisco 49ers at ...

If the Bills do clinch the AFC East on Sunday, they'd be the earliest team to win a division since the New Orleans Saints won ...

Our top pick for the 49ers vs. Bills Week 13 NFL matchup is to bet on the 49ers +6.5 (+100). This betting advice is ...

The Buffalo Bills' home-field advantage will once again be on display on Sunday night with severe weather projected to be on ...

Star receiver George Kittle and the San Francisco 49ers meet the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark ...

Seahawks All Access takes you on the field and the sidelines with all the sights and sounds from the team's Week 12 win over ...