Drs Ursula A. Matulonis and Marisa R. Nucci discuss the future of AI and pathology and how genetics and genomics play a role ...
Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many human diseases, including cancers. However, how molecular machines—protein ...
Enzalutamide is a potent second-generation antiandrogen commonly used to treat hormone-sensitive and castration-resistant prostate cancer (CRPC) patients. While initially effective, the disease almost ...
The following is a summary of “Regulatory Roles of SWI/SNF Chromatin Remodeling Complexes in Immune Response and Inflammatory Diseases,” published in the December 2024 issue of Allergy and Immunology ...
Biophysical chemists from the National University of Singapore (NUS) have uncovered a previously hidden landscape that governs the intracellular organization and dynamics of SWI/SNF chromatin ...
The SWI/SNF protein complex was already known to carry out such changes, but it was unclear whether each of the three variants did so in a unique way or led to distinct macrophage behavior. To learn ...
The FIPO23 trial: First-in-human phase I/II study of XON7 in advanced solids tumors. ATHENA: A phase 1/2 study of AZD5851, a chimeric antigen receptor (CAR) T-cell therapy directed against GPC3 in ...
In eukaryotic cells, nucleosomes—composed of histone octamers—address the topological challenge of DNA packaging by condensing the DNA within the nucleus., crucial for genetic information storage and ...
Cancer cells are often a mess of mutations. About 20% to 25% of cancers involve mutations in a complex of molecules called SWI/SNF. Yet drugs designed to block SWI/SNF activity haven't always worked ...
Most lung adenocarcinoma tumors with EGFR mutations respond to tyrosine kinase inhibitors (TKIs, e.g., osimertinib). Accordingly, there are now >50 different FDA-approved TKIs. Still, acquired ...
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