It's Week 13, and the San Francisco 49ers are at 5-6 in the season. The team travels to Buffalo to take on the leaders of the AFC in a Sunday night showdown.

After its Week 11 party in Buffalo, "The NFL Today" crew is hitting the road again. This time, the NFL on CBS pregame show will broadcast live from Ford Field in anticipation of the Detroit Lions' Week 15 matchup against Josh Allen and the Buffalo Bills.

Watch out for the tables on "Sunday Night Football." The nightcap of Sunday's action will be in northern New York with the Buffalo Bills (9-2) hosting the San Francisco 49ers (5-6). San Francisco has been up and down all season,

Kansas City Chiefs quarterback Patrick Mahomes has been fined more than $14,000 for pantomiming what the NFL deemed a "violent gesture" during a game last week against the Buffalo Bills.

The Kansas City Chiefs will play the Buffalo Bills today. Here's everything you need to know to watch the game.

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.

Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen. Cohen, a SportsLine NFL expert and host of the Friday "Early Edge NFL Props Show" on SportsLine's YouTube page,

Bills: The Buffalo Bills were off in Week 12, so they didn’t move in our rankings. They are still the clear No. 2 team in the AFC, and you can make an argument that they are No. 1 after beating the Chiefs in Week 11.

SportsLine's advanced model has locked in its Week 13 NFL betting picks and football predictions from 10,000 simulations to tell you how to bet NFL games

NFL Today broadcasted its pregame show from Highmark Stadium's Lot 6, outside The Bills Store, ahead of the Buffalo Bills' home contest against the Kansas City Chiefs Sunday. The show is hosted ...