Interferon-Induced Protein with Tetratricopeptide Repeats 3 (IFIT3) plays a dual role in innate immunity and tumor immunity, functioning as both a viral defense molecule and a regulator of tumor ...

Interferon regulatory factor 3 (IRF3) is a key transcription factor in the type I interferon signaling. Its activation must be tightly controlled to efficiently activate innate immunity while avoiding ...

Although the past decade has witnessed substantial scientific progress with the advent of cardioprotective pharmacological agents, most have failed to protect against myocardial ischemia/reperfusion ...

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Clues to the root cause of dysglycemia in obesity have now been uncovered by an international team of researchers, including scientists at the Dasman Diabetes Institute in Kuwait. “Most previous ...

Succinate is at the crossroads of multiple metabolic pathways and plays a role in several immune responses acting as an inflammation signal. However, whether succinate regulates antiviral immune ...

The cGAS-STING pathway is important for immune defense against infection and cancer. STING activation triggers multiple signaling cascades leading to activation of IRF3, NF-κB, and autophagy. By ...

HIV-1 must replicate in cells that are equipped to defend themselves from infection through intracellular innate immune systems. HIV-1 evades innate immune sensing through encapsidated DNA synthesis ...

Alcohol-related liver disease is a leading cause of mortality worldwide. Improved patient outcomes will be driven by advances in our understanding of disease pathogenesis, allowing for the development ...