Phosphorylation of an autophagy-related protein promotes its binding to the endoplasmic reticulum and enables proper growth of the autophagosomal membrane Press Releases Research Life Science and ...

Autophagy is essential to intracellular homeostasis and is involved in the pathophysiology of a variety of diseases. Mechanisms regulating selective autophagy remain poorly understood. The COP9 ...

The autophagosome, which encloses damaged or excess cellular material for degradation, is constructed from lipids supplied by the endoplasmic reticulum (ER) via the lipid transfer protein Atg2.

The autophagosome, which encloses damaged or excess cellular material for degradation, is constructed from lipids supplied by the endoplasmic reticulum (ER), via the lipid transfer protein Atg2.

Parkinson’s disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized pathologically by the loss of dopaminergic neurons in the substantia nigra and the formation ...

That viral claim that your frontal lobe “isn’t fully developed until 25” turns out to be more myth than milestone. Early brain scans showed that gray matter changes dramatically through the teen years ...

As a society, we find ourselves at a crossroads between tradition and scientific understanding. While neuroscience has revealed that the human brain doesn't fully mature until approximately age 25, ...

Oxidative stress induced by 6-OHDA stimulates autophagy flux, which enhances STX17-mediated autolysosome formation, leading to the degradation of autophagosomal contents. However, in response to ...

Tuberculosis is a widely spread disease caused by Mycobacterium tuberculosis (Mtb). The pathogenicity of the pathogen is closely associated with the immune defense mechanisms of the host cells. As key ...

Altmetric provides a collated score for online attention across various platforms and media. See more details Plants distribute many nutrients to chloroplasts during leaf development and maturation.

A research team has discovered a novel mechanism essential for initiating autophagy. The study highlights the role of ZDHHC13, an enzyme that palmitoylates ULK1, in triggering autophagy. This ...