Get everything you need to know about how and where to bet on the Week 15 Rams at 49ers Thursday Night Football game.

With their top two options sidelined, the expectation was that rookie Isaac Guerendo would lead the backfield for the ...

San Francisco 49ers rookie running back Isaac Guerendo is dealing with a foot injury and is listed as questionable for Week 15 against the Los Angeles Rams on T ...

When the Rams take on the 49ers on Thursday night, the veteran quarterback will try to set a personal milestone with another ...

After enduring a grueling three-game losing streak, including two lopsided defeats, the San Francisco 49ers finally found ...

McCaffrey's old backfield mate discussed the trials and tribulations of a season-ending injury on his podcast.

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

With Christian McCaffrey and Jordan Mason on injured reserve, Guerendo made his first NFL start against the Bears. If he ...

More and more you could make an argument the most dangerous job is that of running back for the San Francisco 49ers.

Breaking down all of the good and some of the bad from the 49ers’ much-needed blowout win over the Bears in Week 14.

Kyle Shanahan confirmed his future is firmly with the San Francisco 49ers as far as he's concerned after leading them to a 38-13 victory over the Cleveland Browns to rescue their p ...

Moments after the conclusion of the game, a 44-42 thriller that ended with the Bills dropping only their third game of the ...