The Colts' loss clinched playoff spots for the Bills and Chargers. The 49ers had already clinched their spot in the NFC, and ...

Jordan James will make his season debut, while Jordan Watkins is also active for the first time in a few games.

San Francisco 49ers quarterback Brock Purdy talks about the expectations of the team as the end of the regular season ...

The 49ers and the Colts are set to play each other in the upcoming NFL 2025-26 season game. Here is everything you need to ...

The 49ers just beat the Indianapolis Colts 48-27 and won their 11th game of the season. Last season, they lost 11 games.

LA's NFC team tumbled down the conference's projected playoff seeding ladder. Now, what is Rams' fate after long run atop our ...

Brock Purdy throws a career-high five touchdown passes and Dee Winters returns an interception 74 yards for a TD in a 48-27 ...

Philip Rivers starts again when he takes on the ferocious 49ers on "Monday Night Football." Here's score, highlights, stats ...

Another win stacked up by the San Francisco 49ers. Their offense lit up the Indianapolis Colts in primetime to get the win ...

By winning Monday night’s final regular-season road game in a 48-27 shootout over the Colts, the 49ers remained in control of ...

The San Francisco 49ers have beaten the Indianapolis Colts 48-27 on “Monday Night Football” behind Brock Purdy ’s career-high five touchdown passes. Christian McCaffrey racked up 146 total scrimmage ...

The San Francisco 49ers outlasted the Indianapolis Colts 48-27 on the road to close out Week 16 on Monday Night Football, ...