Before the 2024 NFL season, Sunday night's Week 13 matchup between the Buffalo Bills and San Francisco 49ers might've been ...

San Francisco 49ers quarterback Brock Purdy feels sorry for the brutal injury suffered by Christian McCaffrey.

Daily Fantasy millionaire Mike McClure shares his top NFL DFS picks for Buffalo Bills vs. San Francisco 49ers on SNF ...

The San Francisco 49ers are in dire straights after a blowout loss to the Buffalo Bills, and QB Brock Purdy knows it.

Kirk Cousins threw four interceptions and tossed the Atlanta Falcons’ playoff plans into disarray. Brock Purdy couldn’t ...

This has led to a profound resource drain to the 49ers. They kept up their turn-and-burn roster approach of letting guys ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

The weather outside was frightful at Highmark Stadium in Orchard Park, New York on Sunday night, but the way the San ...

The situation for the San Francisco 49ers is so dire that Brock Purdy had to send a clear and forceful message to his ...

Josh Allen scored a receiving touchdown on a pass he threw in his latest do-everything performance, and the Buffalo Bills ...

The 49ers were absolutely shellacked Sunday for a second straight week as the Buffalo Bills beat them 35-10 on national ...

Follow along for updates throughout the game as the Buffalo Bills take on the San Francisco 49ers at snowy Highmark Stadium.