The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs.

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A ...

San Francisco 49ers running back Christian McCaffrey could be done for the season after just four games. As head coach Kyle ...

Christian McCaffrey is dealing with an injury again. The 49ers running back went down with a knee injury in the second ...

The San Francisco 49ers received some brutal news on Sunday evening. According to head coach Kyle Shanahan, running back ...

The Buffalo Bills easily got past the San Francisco 49ers 35-10 on a snowy Sunday Night Football matchup. Here are winners ...

The San Francisco 49ers' losses to the Green Bay Packers and Buffalo Bills mark the worst two-game stretch by a defending ...

The 49ers were absolutely shellacked Sunday for a second straight week as the Buffalo Bills beat them 35-10 on national ...

San Francisco running back Christian McCaffrey suffered a knee injury that coach Kyle Shanahan described as “potentially” ...

"49ers coach Kyle Shanahan tells reporters that RB Christian McCaffrey suffered a PCL injury that could end his season. Just ...

The San Francisco 49ers' visit to Buffalo could be more painful than expected for Kyle Shanahan following the loss to the ...

Christian McCaffrey's 2024/25 NFL season could be over in a devastating blow to the San Francisco 49ers after the 28-year-old ...