Nathan MacKinnon scored twice as the visiting Colorado Avalanche rattled off five unanswered goals for a come-from-behind 5-4 ...

The San Francisco 49ers and fantasy football players who were relying on the NFC West team's running backs are probably all ...

Seahawks All Access takes you on the field and the sidelines with all the sights and sounds from the Week 13 comeback-victory ...

BUFFALO, N.Y. (WIVB) — Former City of Buffalo Fire Commissioner Garnell Whitfield announced that he is running for Buffalo ...

President and CEO of Buffalo Museum of Science Gary Siddall and Dr. Holly Schreiber joined Most Buffalo in studio Tuesday to ...

With a dominant 35-10 victory over the San Francisco 49ers on Sunday night, the Buffalo Bills clinched the AFC East for a ...

Ricky Pearsall Jr., the 49ers first-round draft pick, was shot through the chest on Aug. 31 in a robbery attempt.

The Seattle Seahawks are in first place in the NFC West after a trio of wins against the San Francisco 49ers, Arizona ...

Guard Ben Bartch and defensive tackle Evan Anderson got their first-ever starts for the 49ers and both played well in snowy ...

The New York State Thruway Authority is asking drivers to slow down and move over after a tractor-trailer hit an attenuator ...

Buffalo mayoral candidate Garnell Whitfield sits down to talk about bringing change, addressing housing issues, and ...

The New York State Thruway Authority is reminding drivers to move over for workers after sharing a video of a tractor-trailer ...