For decades, dopamine has been celebrated in neuroscience as the quintessential "reward molecule"—a chemical herald of pleasure, motivation, and reinforcement. In popular understanding, higher ...

The way the brain develops can shape us throughout our lives, so neuroscientists are intensely curious about how it happens. A new study by researchers in The Picower Institute for Learning and Memory ...

Dopamine plays a more complex and precise role in brain function than previously thought: it not only enhances neural activity, but regulates inhibitory circuits that determine which signals are ...

Developmental electrophysiological adaptations and heat-sensitive proteins, such as TRPV3, in cortical excitatory neurons help maintain stable activity levels when brain temperature rises by 2–3°C ...

Schizophrenia has long been one of medicine’s most puzzling conditions, with genetics offering tantalizing clues but an ...

Background Both host and microbe metabolism of tryptophan (Trp) is altered in diabetes; however, the molecular mechanisms are ...

A multidisciplinary USC research team has identified new compounds that may target a key driver of brain inflammation linked to Alzheimer's disease. Their research just published in the Nature ...

A neural circuit hidden in an understudied region of the brain plays a critical role in turning temporary pain into pain that can last months or years, according to new University of Colorado Boulder ...

Prefoldin 5 stabilises neuronal microtubules and suppresses Tau-mediated neurotoxicity, offering a potential therapeutic target for tauopathies.

An estimated 60% of patients with Alzheimer's disease develop epilepsy or subclinical epileptiform activity over the course of the disease. New-onset seizures in cognitively healthy adults also ...

Novel research highlights effects on flight genes and thermogenesis in honey bees after exposure to dinotefuran, a ...