The vessel will head to the Pacific Ocean.
Disney Cruise Line's summer 2027 lineup offers six Disney-themed cruises to the Caribbean, Europe and Alaska, with Marvel-themed departures from Galveston.
Officials said the project will create more than 2,400 jobs for the Galveston and Port Arthur communities and invest more than $730 million to grow the business in Texas.
Environmental scientists joined alongside anglers and community advocates in opposition to the multiberth cruise terminal.