The San Francisco 49ers have a big decision looming ahead of the Nov. 4 NFL trade deadline after key injuries.

The San Francisco 49ers were dealt another significant injury blow after Sunday's victory over the Atlanta Falcons.

Huff will miss a game or two, while quarterback Brock Purdy is "a reach" to return from his toe injury in Week 8.

Christian McCaffrey totaled 201 yards from scrimmage to lead the 49ers past the Falcons on Sunday night, and in doing so, he ...

San Francisco 49ers linebacker Fred Warner is staying positive despite suffering what could be a season-ending ankle injury.

McCaffrey had a season-high 24 carries for 129 yards, marking his first 100-yard rushing game of the season. It was ...

The 49ers need help after losing Nick Bosa and Fred Warner. Here are the top 10 trade targets to replace them.

The San Francisco 49ers continue to lose quality players to injury, as cornerback Renardo Green went down against the Atlanta ...

Tight end George Kittle, out since Week 1 with a hamstring tear, returned to the 53-man roster after missing five games while ...

Fred Warner has undergone successful surgery, and he is expected to resume on-field work for the 49ers this offseason. More ...

The 49ers’ remaining schedule would be challenging even with Fred Warner and Nick Bosa. Without them? Good luck.

San Francisco 49ers All-Pro linebacker Fred Warner suffered an injury in Week 6. His wife had positive news for his recovery.