pharmaphorum

NICE backs Biogen's Vumerity for multiple sclerosis

Patients with relapsing-remitting multiple sclerosis (RRMS) in England, Wales and Northern Ireland can now access treatment with Biogen's oral therapy Vumerity, after NICE recommended the drug for ...
Nature

Oral fumarate reduces the incidence of brain lesions in patients with multiple sclerosis

A placebo-controlled, dose-finding, phase II trial testing the efficacy and safety of BG00012, an oral formulation of dimethyl fumarate, reports a reduced incidence of gadolinium-enhancing ...
Nature

Open conformation of a flavocytochrome

Fumarate reductases and succinate dehydrogenases play central roles in the metabolism of eukaryotic and prokaryotic cells. A recent medium resolution structure of the Escherichia coli fumarate ...
pharmaphorum

Update: FDA clears first generic of AZ's blockbuster Symbicort

Viatris (formerly Mylan) has become the first drugmaker to win full FDA approval for a generic version of AstraZeneca's top-selling respiratory drug Symbicort, although launch plans remain uncertain ...
ascopubs.org

Multi-omics analyses and molecular subtypes to provide potential therapeutic implications in fumarate hydratase-deficient renal cell carcinoma.

Impact of Latino ethnicity on the gut microbiome composition of patients with metastatic renal cell cancer (mRCC). This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract ...