Promoter-proximal pausing by RNA polymerase II (Pol II) ensures gene-specific regulation and RNA quality control. Structural considerations suggested a requirement for initiation-factor eviction in ...
A protein that helps push a replicating cell through the cell cycle also mediates the processing and generation of mature microRNA, according to new research. Cyclin D1, a protein that helps push a ...
Circle Pharma, a leader in macrocycle drug discovery and development, announced the submission of its first Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA) ...
Incidental lymphoma during sentinel lymph node biopsy for breast cancer. Background: To evaluate the cyclin D1 expression in breast cancer patients and to investigate its correlation with other ...
Proxygen GmbH has disclosed molecular glue degraders comprising a cullin-ring E3 ligase (CRL) binding moiety acting as cyclin-dependent kinase 12 (CDK12)/cyclin K degradation inducers. They are ...
SAN FRANCISCO--(BUSINESS WIRE)--Circle Pharma announced today that two poster presentations at the American Association for Cancer Research (AACR) Annual Meeting held April 14-19, in Orlando, Florida, ...
SAN FRANCISCO--(BUSINESS WIRE)--Circle Pharma, in collaboration with the laboratory of Violeta Serra, Ph.D., at Vall d’Hebron Institute of Oncology (VHIO) in Barcelona, Spain, recently unveiled ...
More than 20 years after the discovery of combination antiretroviral therapy (ART), complete eradication of HIV infection has not yet been achieved. While ART controls viral replication, it is not a ...
Cyclin-dependent kinase 9 (CDK9) is a member of the CDK family, which is a very important group of proteins involved in the control of the cell cycle. CDKs may be classified as multifunctional enzymes ...
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