Nature

Inhibition of apoptosis can be accompanied by increased Bim levels in T lymphocytes and neutrophil granulocytes

There is at present no known reliable assay of Bim activation. Although the release from the microtubule cytoskeleton may be a measure of Bim activity, 7 activation of Bim may be regulated in a ...
Nature

Essential role for Bim in mediating the apoptotic and antitumor activities of immunotoxins

Protein synthesis is crucial for regulating cell homeostasis and, when unrestricted, it can lead to tumorigenesis. Immunotoxins derived from Pseudomonas exotoxin are antibody–toxin fusion proteins ...
ascopubs.org

BIM and SHP2 expression levels to predict clinical outcome to EGFR tyrosine kinase inhibitors (TKI) in EGFR-mutant non-small-cell lung cancer (NSCLC) patients (p).

Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinomas patients with EGFR mutations. This is an ASCO Meeting Abstract from the 2015 ASCO Annual Meeting I ...
ascopubs.org

Effect of BIM and mTOR expression on clinical outcome to erlotinib in EGFR-mutant non-small cell lung cancer (NSCLC) patients (p).

Observational study of treatment with epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) in activating EGFR-mutation–positive (EGFRm+) advanced or recurrent non-small cell lung ...
Science Daily

New biomarker 'bim' could enable smarter treatment for melanoma patients

Over the past few years, checkpoint blockade immunotherapies have revolutionized cancer treatment and helped many patients who were previously considered untreatable. Now, new discoveries could help ...