eLife4h
Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity
The function of human airway macrophages can be therapeutically manipulated by targeting cellular metabolism to support immunity in the lung, aiding the design of innovative strategies in respiratory ...
eLife3h
Circuit function is more robust to changes in synaptic than intrinsic conductances
This study provides valuable insights into the differential impact of intrinsic and synaptic conductances on circuit robustness, emphasizing intrinsic plasticity as a crucial but often overlooked ...
eLife5h
AI-enabled Alkaline-resistant Evolution of Protein to Apply in Mass Production
This work presents a valuable exploration of AI-assisted protein engineering, particularly in designing a VHH antibody with enhanced resistance and stability to extreme environments. However, the ...
eLife7d
How cancer-associated fibroblasts promote T-cell exclusion in human lung tumors: a physical perspective
Tumor cells transform fibroblasts into cancer-associated fibroblasts, which have an important immunosuppressive activity on which growth, invasion, and metastasis depend. These activated fibroblasts ...
eLife3d
A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus
This valuable study proposes a novel rapid-entry mechanism of S. aureus that involves the rapid release of calcium from lysosomes. The strength of the paper lies in a very interesting hypothesis; what ...
eLife4d
Interplay of condensate material properties and chromatin heterogeneity governs nuclear condensate ripening
In this potentially valuable study, the authors employed in vivo experiments and theoretical modeling to study the growth dynamics of nuclear condensates. They observed that condensates can exhibit ...
eLife4d
Brain Activity: Unifying networks of a rhythm
Combining electrophysiological, anatomical and functional brain maps reveals networks of beta neural activity that align with dopamine uptake.
eLife4d
Spinal V1 inhibitory interneuron clades differ in birthdate, projections to motoneurons, and heterogeneity
Major differences among the main spinal V1 inhibitory interneuron subgroups were revealed based on neurogenesis, circuit placement, and motoneuron targeting, and Foxp2-V1 interneurons were identified ...
eLife7d
Primosomal protein PriC rescues replication initiation stress by bypassing the DnaA-DnaB interaction step for DnaB helicase loading at oriC
Department of Molecular Biology, Kyushu University Graduate School of Pharmaceutical Sciences, Fukuoka, Japan ...
eLife4d
Human cytomegalovirus infection coopts chromatin organization to diminish TEAD1 transcription factor activity
This interesting study presents valuable information on how human cytomegalovirus (HCMV) infection disrupts the activity of the TEAD1 transcription factor, leading to widespread chromatin alterations.
eLife7d
Adolescent alcohol exposure promotes mechanical allodynia and alters synaptic function at inputs from the basolateral amygdala to the prelimbic cortex
The prelimbic (PrL) cortex is vulnerable to insult from adolescent alcohol exposure and receives input from the basolateral amygdala (BLA) while sending projections to the ventrolateral periaqueductal ...
eLife12d
The eLife Model: An update on progress following changes in Web of Science indexing status
Following the decision that eLife will not receive an Impact Factor in 2025, we share an update on how our model is doing ...