The San Francisco 49ers received some brutal news on Sunday evening. According to head coach Kyle Shanahan, running back Christian McCaffrey suffered a potentially season-ending PCL injury in their 35–10 loss against the Buffalo Bills.

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A knee injury knocked the running back out of Sunday night's Week 13 matchup with the Buffalo Bills,

San Francisco 49ers running back Christian McCaffrey could be done for the season after just four games. As head coach Kyle Shanahan relayed after the

The 49ers were among the preseason favorites to win the Super Bowl, but now they look like long shots to make the playoffs. Coach Kyle Shanahan says

Christian McCaffrey's 2024/25 NFL season could be over in a devastating blow to the San Francisco 49ers after the 28-year-old running back suffered a suspected posterior cruciate l

"49ers coach Kyle Shanahan tells reporters that RB Christian McCaffrey suffered a PCL injury that could end his season. Just a nightmare of a season," Rapoport wrote on X. Another reporter spotted McCaffrey walking past him with crutches and a brace on his right knee.

Purdy missed the 49ers' Week 12 contest versus the Green Bay Packers last Sunday with a right shoulder injury—a game San Francisco lost 38–10. The 25-year-old was limited in practice this week on Wednesday and Thursday, and was a full participant on Friday. He's officially listed as questionable for Sunday.

San Francisco head coach Kyle Shanahan discussed what it will take for the 49ers to ignite receiver Deebo Samuel’s production.

The NFL is reviewing the sideline scuffle between San Francisco 49ers linebacker Dre Greenlaw and Philadelphia Eagles' head of security, Dom DiSandro. Both individuals were ejected from Sunday's game.

Dre Greenlaw practiced for the first time this week since he tore his Achilles in the Super Bowl. Here's what head coach Kyle Shanahan said about Greenlaw's wee