By Alexander Cornwell, Parisa Hafezi and Jeff Mason TEL AVIV/DUBAI/WASHINGTON (Reuters) -Iranian missiles struck major Israeli cities on Monday while Israel's prime minister said his country was on its way to eliminating "threats" from nuclear and missile facilities in Iran and civilian casualties mounted on both sides.

The Iranian regime faces pressure as Israel strikes military targets, with Iranian Americans advocating for the overthrow of what one Iranian American describes as a "paper tiger regime."

Israel’s military said it hit command centers of Iran’s Revolutionary Guard, while Iranian strikes overnight killed several people.

President Donald Trump opposed an Israeli plan to kill Iran’s Supreme Leader Ayatollah Ali Khamenei, according to two sources, amid ongoing waves of tit-for-tat strikes between Israel and Iran as the US president is making publicly and privately clear he prefers to keep the United States out of the fray for now.

There were reported explosions at Iran's main uranium enrichment facility at Natanz, while Iran's elite Revolutionary Guards corps said its top commander, Hossein Salami, had been killed. The IDF said 200 fighter jets took part in the strikes, hitting more than 100 targets.