The c-Myc cellular oncogene has diverse activities, including transformation, proliferation, and apoptosis. These activities are dependent on the ability of c-Myc to regulate gene transcription. c-Myc ...

Effects of c-Myc overexpression on the DNA damage-induced G2/M checkpoint were studied in finite lifespan, normal human mammary epithelial cells (HMECs). Previously, we showed that c-Myc attenuates G1 ...

Preclinical studies have highlighted how (E,E)-bisantrene silences c-MYC gene expression via G4-DNA binding and stabilization leading to clinically relevant and broad anticancer activity ...

Asymmetric cell division plays an important role during the development of our nervous and digestive systems. It is thought that T cells, a type of immune cell, can also divide asymmetrically, giving ...

The c-myc gene is commonly activated in a variety of human tumors. As a new report in the October 1 issue of Genes & Development shows, scientists are gaining a better understanding as to why. Dr.

Researchers have determined the mechanism used by c-Myc to increase the expression of all active genes in cancer cells. Elevated levels of c-Myc are linked to increased rates of metastasis, disease ...

Scientists at the Karolinska Institutet in Sweden have found a new region in the c-Myc oncogene that would allow the development of a binding compound to target it. Their discovery is based on a ...

Myc is one of the most frequently mutated, widely studied, and overexpressed genes implicated in cancer. Most mutations in the myc gene lead to its constitutive expression. The myc gene codes for the ...

The Innovation Center of NanoMedicine reported in ACS Nano together with the group of Prof. Yu Matsumoto of Otorhinolaryngology and Head and Neck Surgery and the group of Prof. Horacio Cabral of the ...

Scientists have long known that in tumor cells, elevated levels of MYC’s protein product, c-Myc, are associated with poor clinical outcomes, including increased rates of metastasis, recurrence, and ...