CBS's popular sitcom Two and a Half Men, starring Charlie Sheen and Jon Cryer, debuted on September 22, 2003. The series wrapped up after twelve seasons in 2015.

Twenty-two years ago, Two and a Half Men starring Charlie Sheen, Jon Cryer and Angus T. Jones premiered. Keep reading to see the cast then and now.

Charlie Sheen is sharing his life story in two upcoming projects and a PEOPLE cover story — and he wants Jon Cryer to know he ...

Sheen offers congratulations and a warning to beware 'Planet Chuck [Lorre]' May 13, 2011 — -- The suspense didn't last long: today, CBS and Warner Bros. confirmed that Ashton Kutcher will replace ...

Nothing gets in the way of being a womanizer more than when your divorced brother and his jokester young son move into your Malibu home, which is exactly what happens to Charlie Harper (Charlie Sheen) ...

Charlie Sheen was written out of 'Two and a Half Men' in Season 9, with co-star Jon Cryer revealing is he's up for a reunion.