ST. LOUIS -- If you've ever popped a tablet for a tummy ache, chances are it was made in Missouri. For decades, Tums has rolled off billions of antacid tablets from its red brick building at 320 S.

James Howe made a good living from heartburn and acid indigestion. His grandfather invented Tums, the antacid tablet that’s still made in a five-story plant across from Busch Stadium. Mr. Howe was the ...

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