That all changed in 1938, after the deaths linked to Elixir Sulfanilamide had become a national scandal. Six years earlier, German pathologist and bacteriologist Gerhard Domagk discovered that a ...

They then treated the wound with sulfanilamide drugs. For the benefit of the German Army, whose frontline soldiers suffered greatly from gas gangrene, a type of progressive gangrene, doctors at ...

To test this hypothesis these workers administered sulfanilamide, a specific inhibitor of carbonic anhydrase, 2 to dogs, presumably inhibiting the formation of carbonic acid in the renal parenchyma.