NFL Week 10 odds, picks, predictions, TV channel, streaming information for the Sunday football game between Los Angeles Rams and San Francisco 49ers.

The NFL season continues when the Houston Texans host the San Francisco 49ers Sunday. Start time, how to watch, streaming and NFL TV schedule.

The Los Angeles Rams and the San Francisco 49ers take the field in one of many compelling matchups on the NFL schedule in Week 10. In terms of live coverage, we have what you need to know about Week 10 of the NFL here. Check out the piece below.

Thursday Night Football schedule, TV channel, time, streaming information for San Francisco 49ers vs Los Angeles Rams NFL Week 5 game on Oct. 2, 2025.

The last of these postseason games came back in 2011 in the NFC Championship game, when the Giants defeated the 49ers on the road, 20-17, to cap off their improbable run to Super Bowl XLVI, where they went on to beat the New England Patriots on that stage for the second time in four years.

The Niners were fresh off a roster revamp, saying goodbye to nearly 20 players in the offseason, 15 of whom landed deals elsewhere worth up to a maximum of $341.5 million. In their place, the 49ers leaned into their youth, with an 11-man draft class and a free agent group that had no marquee players.

Despite their records, the Cardinals have a better point differential than the 49ers. Arizona has scored 180 and allowed 171, while San Francisco has scored 194 and allowed 188. The 49ers have played in one more game though so here’s how that breaks down:

Is Jauan Jennings the WR1 for the 49ers now? With lingering injuries to Ricky Pearsall and Brandon Aiyuk, John breaks down Jauan Jennings' fantasy football outlook heading into Week 10 of 2025.

Few would have expected the lowly New York Giants to be a matchup of particular importance for the San Francisco 49ers, but the stakes have heightened entering Sunday, columnist Ann Killion writes.

If the Rams beat the 49ers, chances of winning the NFC West and finishing ahead of the 49ers go up dramatically. They’ll be 7-2 and 2-2 in the division, handing a second conference loss to the 49ers. And that’s really what the Rams need — or gotta — have happen. This is the start of the playoffs to get to the playoffs.