The last of these postseason games came back in 2011 in the NFC Championship game, when the Giants defeated the 49ers on the road, 20-17, to cap off their improbable run to Super Bowl XLVI, where they went on to beat the New England Patriots on that stage for the second time in four years.

San Francisco is a 2.5-point favorite in the latest 49ers vs. Giants odds from SportsLine consensus, while the over/under for total points scored is 48.5. The 49ers are -143 money line favorites (risk $143 to win $100),

The Giants and 49ers meet in Week 9 of the 2025 NFL season. Here's how to watch and more on this NFC showdown at MetLife Stadium this weekend.

Former Tennessee baseball head coach Tony Vitello will be introduced as the Giants' manager in MLB on Thursday.