Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota, USA Correspondence to Dr M J Ackerman, Long QT Syndrome Clinic and the Mayo Clinic Windland Smith ...
February 3, 2006-- A recent analysis of the prospective, population-based Rotterdam Study found that prolongation of the heart-rate corrected QT (QTc) interval increased the risk of sudden cardiac ...
A phase II, randomized trial using the small molecule tyrosine kinase inhibitor lapatinib as a first-line treatment in patients with FISH positive advanced or metastatic breast cancer ...
Tyrosine kinase inhibitors (TKIs) are associated with prolongation of the QTc interval on the electrocardiogram (ECG). The QTc-interval prolongation increases the risk of life-threatening arrhythmias.
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