Researchers from IOCB Prague are furthering the understanding of how medicines work and what it takes to develop their most effective variants. In one current study, they have focused on the disease ...

Xiaoyan Liu, Weidi Xiao, Yanan Zhang, Sandra E. Wiley, Tao Zuo, Yingying Zheng, Natalie Chen, Lu Chen, Xiaorong Wang, Yawen Zheng, Lan Huang, Shixian Lin, Anne N ...

The proteasome is a fundamental component of eukaryotic cellular machinery, responsible for the precise degradation of intracellular proteins. By orchestrating the breakdown of both misfolded and ...

One fundamental feature of neurodegenerative diseases is a breakdown in communication. Even before brain cells die, the ...

Many therapeutic targets escape druggability by mysterious molecular motions that cannot be precisely visualized. This ‘dark-world’ reality is particularly augmented in the ubiquitin-proteasome system ...

Recent research from the lab of Dr. Nicolas Lehrbach, an Assistant Professor in the Basic Sciences Division at Fred Hutch, discovered that altering nucleotide metabolism may bypass proteasome defects ...

BERLIN--(BUSINESS WIRE)--Booster Therapeutics, a biotechnology company pioneering a new class of proteasome activator medicines to treat neurodegenerative and other diseases, launched today with the ...

The typical job of the proteasome, the garbage disposal of the cell, is to grind down proteins into smaller bits and recycle some of those bits and parts. That's still the case, for the most part, but ...

• The ubiquitin 26S proteasome (26SP) system efficiently degrades many key regulators of plant development. 26SP consists of two subcomplexes: the catalytic 20S core particle (CP) and the 19S ...

Booster Therapeutics has launched with $15 million in seed financing and a mission to take on the current crop of targeted protein degraders. The Berlin-based biotech is working on a new class of ...

Like any big city, Dr. Nic Lehrbach’s hometown of Sydney, Australia, was in a constant state of change. Old buildings would come down and almost just as quickly new ones would go up. Important to any ...