NFL, Week 10

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Week 10 NFL odds, lines, best bets, predictions: Computer model likes Buccaneers and 49ers
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 on a sizzling 47-29 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.

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2025 NFL Odds Week 10: Lines, Spreads for all 14 Games
NFL Week 10 odds, betting lines for every game
NFL Week 10 predictions, ESPN matchup predictor's picks, win probabilities for this week
ESPN Analytics has revealed its Matchup Predictor numbers for the 14 games in the league this week, and they offer some interesting win probabilities.

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Jacoby Brissett outduels Dak Prescott on MNF as Cardinals snap losing streak
Cardinals vs. Cowboys MNF Score, Updates: Arizona Heads to Dallas After Bye Week
Kyler Murray or Jacoby Brissett? Joe Buck, Troy Aikman talk Arizona Cardinals QB situation
"There's no question that Jacoby Brissett has elevated this offense over the last two weeks," Aikman said.

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Cardinals beat Cowboys to snap five-game losing streak: Live updates and reaction from NFL ‘Monday Night Football’
Cowboys vs. Cardinals recap: Dallas humiliated on Monday night as season slips away

Broncos vs. Raiders prediction, odds, line, start time: 'Thursday Night Football' picks from proven model

For the NFL Week 10 'Thursday Night Football' game of Raiders vs. Broncos, the model is leaning Over the total, projecting 47 total points. It also says one side of the spread hits over 60% of the time in an A-rated pick. See what it is at SportsLine.
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NFL Odds Update: Which Teams Are Rising and Falling

The 2025 NFL season reaches its midpoint with plenty of drama, surprises, and shifting narratives. Teams once counted out have surged.
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