ascopubs.org

Tumor Mismatch Repair Immunohistochemistry and DNA MLH1 Methylation Testing of Patients With Endometrial Cancer Diagnosed at Age Younger Than 60 Years Optimizes Triage for ...

Population-level identification of patients with MMR mutation-positive endometrial cancer is optimized by stepwise testing for tumor MMR IHC loss in patients younger than 60 years, tumor MLH1 ...
EurekAlert!

Study reveals somatic mutation profile of colorectal tumor with simultaneous APC and MLH1 germline mutations

Recently, a collaborated research group from Hefei Institutes of Physical Science (HFIPS) of Chinese Academy of Sciences (CAS) and The Second Hospital of Anhui Medical University dissected, for the ...
ascopubs.org

MSH2 Mutation Carriers Are at Higher Risk of Cancer Than MLH1 Mutation Carriers: A Study of Hereditary Nonpolyposis Colorectal Cancer Families

PATIENTS AND METHODS: Clinical and pathologic data were collected from 138 families with HNPCC. Mutation analyses were performed for all families. Survival analysis was used to calculate the ...
Cure Today

Having a Hereditary Cancer Syndrome Has Changed My Life

After learning that I had Lynch syndrome and a MLH1 mutation, I changed my lifestyle to hopefully prevent a cancer diagnosis. After meeting with a genetic counselor, undergoing genetic testing for ...
Kaleido Scope

Genomic Diagnostics and Bioinformatics launches three new laboratory tests

This initiative was led by Alexander C. Mackinnon, M.D., Ph.D., Robert B. Adams Endowed Professor, Executive Vice Chair, Division Director, Genomic Diagnostics and ...