Telomerase solves this problem by adding single-stranded TTAGGG repeats to the telomere end. As for the lagging-strand, DNA synthesis should not have a problem.

To study DNA replication in vitro, Yeeles assembled replisomes with Saccharomyces cerevisiae proteins capable of performing complete leading- and lagging-strand replication.

The process begins by unzipping DNA's ladder-like structure, resulting in two strands called the leading and lagging strands. A molecular construction crew then assembles the missing halves of the ...

An enduring mystery of 'lagging strand' DNA replication The DNA replication process is carried out by multiple protein complexes with highly specialized functions, including the unwinding of DNA ...