Nature

Determinants of visual acuity outcomes in eyes with neovascular AMD treated with anti-VEGF agents: an instrumental variable analysis of the AURA study

To identify the strongest variable(s) linked with the number of ranibizumab injections and outcomes in AURA, and to identify ways to improve outcomes using this association. Data were analyzed from ...
Nature

Using instrumental variables to disentangle treatment and placebo effects in blinded and unblinded randomized clinical trials influenced by unmeasured confounders

Here we present a statistical approach to disentangle treatment and placebo effects using instrumental variables 14,15,16 in randomized experiments. An instrumental variable (IV) is statistically ...
Drexel University

Instrumental Variable Methods for Cancer Comparative Effectiveness Studies: Do they help or hurt?

The department of Epidemiology and Biostatistics at Dornsife presents Nandita Mitra, PhD, professor of Biostatistics in the department of Biostatistics at University of Pennsylvania. Bias due to ...
ascopubs.org

Use of Instrumental Variable Analyses for Evaluating Comparative Effectiveness in Empirical Applications of Oncology: A Systematic Review

Results of Phase III Randomized Trial for Use of Docetaxel as a Radiosensitizer in Patients With Head and Neck Cancer, Unsuitable for Cisplatin-Based Chemoradiation Sixty-five empirical papers were ...
uni

Instrumental Variables

A frequent problem in the estimation of linear regression models is that the predictors are correlated with the error term contained in the regression equation. To ...