The genomes of influenza viruses consist of multiple segments of single-stranded negative-sense RNA. Each of these segments is bound by the heterotrimeric viral RNA-dependent RNA polymerase and ...

Influenza virus polymerase subunits co-evolve to ensure proper levels of dimerization of the heterotrimer. PLOS Pathogens , 2019; 15 (10): e1008034 DOI: 10.1371/journal.ppat.1008034 Cite This Page : ...

The overall goal of this project is to identify new therapies that target influenza virus replication. The global health burden of annual influenza epidemics coupled with the emergence of highly ...

This article describes the structure of the influenza A virus. ... Each vRNA segment forms a helical hairpin in shape, and is bound by the heterotrimeric RNA polymerase complex.

Polymerase component: PB1–PA interaction Polymerase function (e.g., T-705*) ... Contained within this matrix shell is the viral RNA genome, which (for influenza A viruses) ...

Purdue University researchers now have developed an innovative, paper-based diagnostic test for rapidly detecting avian ...

The influenza virus polymerase complex has received considerable attention as a target for developing antiviral agents. 3,4 The polymerase heterotrimer is composed of three protein subunits ...

To fight the virus that causes influenza, one of the avenues being explored by scientists is the development of drugs capable of destabilising its genome, made up of eight RNA 1 molecules.

Scientists have now deciphered the structure of the avian influenza virus's polymerase when it interacts with a human protein ... making copies of the viral RNA to package into new viruses.

Researchers in Europe and the United States have demonstrated the potential of the influenza drug enisamium as a treatment for infection with severe acute respiratory syndrome coronavirus 2 (SARS ...

To fight the virus that causes influenza, one of the avenues being explored by scientists is the development of drugs capable of destabilizing its genome, which is made up of eight RNA molecules.