Huntington's disease (HD) is a progressive neurodegenerative disorder caused by a mutation in the gene huntingtin and characterized by motor, cognitive and psychiatric symptoms. Huntingtin contains a ...

The mutant protein that causes Huntington disease blocks axonal traffic by putting the molecular equivalent of the wheel-locking “boot” on motor proteins, according to a paper published online June 14 ...

Huntington's disease is a rare genetic disorder and a representative neurodegenerative disease, characterized by loss of motor control, cognitive decline, and psychiatric problems. An international ...

Determining the three dimensional structure of the huntingtin protein could help develop new treatments for Huntington's disease. Mutations on a single gene, the huntingtin gene, are the cause of ...

Just in time for the holidays, research shows that the protein that causes Huntington disease is liberally decked out with phosphates, acetyl groups, SUMO, and ubiquitin—all of which influence its ...

Huntington's disease is a genetic neurodegenerative disorder caused by mutations in the protein huntingtin and characterized by involuntary dance-like movements, severe behavioural changes and ...

This voice experience is generated by AI. Learn more. This voice experience is generated by AI. Learn more. New gene therapies such as AMT‑130 are beginning to slow Huntington’s disease progression, ...

Researchers have elucidated key steps in the ubiquitin tagging of the mutated huntingtin protein, providing hope for future therapies. There is no known cure for Huntington's disease. A genetic ...

Researchers have revealed new clues to how a defective form of the huntingtin protein may cause the deadly changes that lead to Huntington's disease -- by potentially disrupting the process of ...

Two serine residues within the first 17 amino acid residues of huntingtin (N17) are crucial for modulation of mutant huntingtin toxicity in cell and mouse genetic models of Huntington's disease. Here ...

In 1993, scientists discovered that a single mutated gene, HTT, caused Huntington's disease, raising high hopes for a quick cure. Yet today, there's still no approved treatment. One difficulty has ...