They engineered a genetically modified HIV virion that was capable of infecting the cell but incapable of reproducing inside it. The virion was programmed to produce a fluorescent form of integrase.

A mutation factory The investigators believe the proteins that make up the HIV virion are being assembled at the site of the bridge and then directly moved to the cell being infected.

Recent discoveries about the way that HIV infects cells are propelling the development of a broad spectrum of promising new antiviral drugs, according to an invited commentary on the topic in the ...

They engineered a genetically modified HIV virion that was capable of infecting the cell but incapable of reproducing inside it. The virion was programmed to produce a fluorescent form of integrase.

Duel to the Death Inside HIV-Infected Cells Discovery of Shadowy Enzyme and Its Nemesis May Prove Key Step in Defeating the Virus That Causes AIDS ...

Once inside, the virion reprograms the genetic material of the immune cell to produce more HIV virions. In this way, HIV disables the disease-fighting 'bodyguards' in our blood and turns them into ...

Article Published: August 2001 Inhibition of HIV-1 virion production by a transdominant mutant of integrase interactor 1 Eric Yung, Masha Sorin, Achintya Pal, Errol Craig, Alexei Morozov, Olivier ...

An HIV virion attaches to this host cell initially by connecting to a CD4 receptor. From there, it makes its way into the cell, pulling the viral and cellular membranes together, fusing them and ...

This illustration shows how the envelope proteins covering the surface of an HIV virion (1, 2) bind to a host cell (3, 4). The trimeric MPER region of gp41 is shown in red and can be disabled by ...

By contrast, the HIV virion was known to have an asymmetrical form, and it has also been established that many viruses have some variance in the stable structures they can assume.

A mutation factory The investigators believe the proteins that make up the HIV virion are being assembled at the site of the bridge and then directly moved to the cell being infected.