Third, Nef enhances virion infectivity and viral replication 112. This effect is mediated by Nef present in HIV virions and is due, at least in part, to the ability of Nef to induce actin ...

The resulting complex of viral cDNA and virion proteins, now referred to as the pre-integration complex (PIC), is transported to the nucleus (Fig. 1). Figure 1: Models of flap-dependent HIV ...

Enhancement of HIV-1 Infectivity. Early work on this topic ... protein other than CD4 that blocks the function of Env in the virion. Nef enhances infectivity by downregulating this unknown protein ...

Dr. Ochsenbauer-Jambor investigates the role of DC-SIGN in the capture and trans-infection of HIV-1 with special emphasis on virion internalization pathways and the acquisition of selective ...