Hydroquinone has long been used as the gold standard treatment for hyperpigmentation, yet despite its effectiveness, it has been associated with a severe adverse reaction known as exogenous ochronosis ...
Tyrosinase (Tyr) catalyzes hydroquinone (HQ) oxidation via two main pathways. The HBQ pathway directly oxidizes HQ to 2-hydroxy-1,4-benzoquinone (HBQ), which dimerizes and forms hydroquinone-eumelanin ...
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