Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a double-strand break involves the severing of both strands of the DNA double ...

Following a double-strand DNA break, an enzyme called PARP1 helps hold the two strands together —like superglue— and creates a safe zone for other proteins to come repair the damage. We don’t exactly ...

A double-strand break (DSB) is a type of DNA damage where both strands of the DNA helix are cut or broken at the same location, causing a complete discontinuity in the DNA molecule. Unrepaired or ...

The protooncoprotein N-Myc, which is overexpressed in approximately 25% of neuroblastomas as the consequence of MYCN gene amplification, has long been postulated to regulate DNA double-strand break ...

An illustration of light purple Cas9 enzyme being guided to light blue DNA against dark blue background. The enzyme Cas9 (top) can cause double-strand breaks in DNA (bottom). Credit: Shutterstock ...