For a living cell to divide successfully, each daughter cell must inherit the correct genetic material. In eukaryotes, segregation of duplicated chromosomes is performed by the mitotic spindle, a ...

Advancements in genome sequencing have challenged the long-standing belief that the position of the centromere in the chromosome is fixed. Researchers from Okayama University, Japan, have analyzed ...

Super-resolution microscopy image of a mitotic chromosome (white) with the centromeres of each sister chromatid depicted in orange. Each centromere consists of two distinct chromatin subdomains ...

Despite the immense amount of genetic material present in each cell, around three billion base pairs in humans, this material needs to be accurately divided in two and allocated in equal quantities.

“This work is really important because the X chromosome has largely been excluded from genetic studies in the past,” said Amy Roberts, a molecular epidemiologist at King’s College London who was not ...

Accurate chromosome segregation and cell division are central to maintaining genomic integrity and ensuring proper development and tissue homeostasis. These processes rely on a complex network of ...