In hepatocytes, bile acids are secreted into bile canaliculi by bile salt export pump (BSEP), cholesterol is secreted by ATP binding cassette subfamily G member 5 (ABCG5) and ABCG8 heterodimer and ...

Poisoning with paracetamol (acetaminophen—APAP) is a common cause of liver failure. However, not all the correlations that lead to liver damage from APAP are yet known. Especially the role of bile ...

(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...

The gall bladder is seldom brought up in conversation until it is out of order. This little, pear-shaped organ lies just under the liver and is the main player in digestion by storing and releasing ...

Bile duct cancer can cause a buildup of fluid in the lining of the abdomen, called ascites. This can lead to abdominal bloating and discomfort. Bile ducts are part of the digestive system. They are ...