Sideways discovery rewrites the rules of antigen presentation

A new discovery about how cells communicate with each other in the body's immune system has revealed deeper insights for an ...
EurekAlert!

Research spotlight: Basal cell carcinoma’s low immunogenicity is associated with suppression of antigen presentation stemming from its cell of origin

Basal cell carcinoma has low immunogenicity. Tumor cells express Foxc1 protein (red), which suppresses HLA class I (green) in the tumor cells. Compromised antigen presentation ranks among the top ...
Nature

MHC Class II Molecules and Antigen Presentation

MHC Class II molecules are integral to the adaptive immune response, serving as specialised antigen-presenting proteins on the surface of professional antigen-presenting cells. They bind peptide ...

From immune evasion to activation: A new cancer vaccine strategy

A research team led by Professor Chen Peng from the College of Chemistry and Molecular Engineering at Peking University has ...
ascopubs.org

Effect of BCL9/BCL9L inhibition–derived Th1 cells on dendritic cells–mediated antigen presentation in hepatocellular carcinoma and on the efficacy of CAR-T immunotherapy.

Liquid biopsy-based prediction of clinical benefit from immune checkpoint inhibitors in advanced biliary tract cancer. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This ...
Nanowerk

Understanding Antigens in the Immune System and Biotechnology

An antigen is any substance that can trigger an immune response in the body. Antigens are typically proteins or polysaccharides that are recognized as foreign or potentially harmful by the immune ...