Every year, more than 100 million animals are used globally in biomedical research, yet over 90% of drugs that appear effective in animal trials fail during human clinical testing. 1 This staggering ...

A fundamental challenge in preclinical research is accurately predicting human responses using conventional animal models. Traditional approaches often fail to adequately model human disease, creating ...

Researchers at Helmholtz Munich and the Technical University of Munich (TUM) have developed Nicheformer, the first large-scale foundation model that integrates single-cell analysis with spatial ...

Animals, from worms and sponges to jellyfish and whales, contain anywhere from a few thousand to tens of trillions of nearly genetically identical cells. Depending on the organism, these cells arrange ...

The team observed the emergence of the three-dimensional embryo-like structures under a microscope in the lab. These started producing blood (seen here in red) after around two weeks of development - ...