Pancreatic cancer is a devastating disease with poor prognosis. This warrants the development of novel therapies including gene therapy. However, clinical studies have demonstrated poor efficacy of ...

AstraZeneca and the University of Oxford offered a promising but confusing early look at late-stage data for their experimental adenoviral vector vaccine for COVID-19. The preliminary results suggest ...

Adenoviral vectors have emerged as a pivotal platform in gene therapy owing to their efficient gene delivery and high transgene expression. Their application spans from vaccine development to ...

Purpose: We investigated the feasibility, safety, and biologic activity of adenovirus-mediated p53 gene transfer in patients with locally advanced bladder cancer. Results: Thirteen patients received a ...

In a recent study posted to the bioRxiv* server, researchers assessed the immunogenicity of the self-developed recombinant adenovirus vector (rAd5) vaccine on macaques. They evaluated the efficacy of ...

Three European biotech companies agreed to collaborate on the development and large-scale manufacture of a novel adenoviral vector-based vaccine against COVID-19. The vaccine candidate is expected to ...

Ad5 vectors are the most commonly used adenovirus vector. Ad5 vectors transduce a wide range of cell types. They utilize the Coxsackie-Adenovirus Receptor (CAR) to enter cells. Transduction efficiency ...

Open-Label, Multicenter, Randomized, Phase III Study Comparing Oral Topotecan/Cisplatin Versus Etoposide/Cisplatin As Treatment for Chemotherapy-Naive Patients With Extensive-Disease Small-Cell Lung ...

Biological assays in established and primary cells can greatly aid the drug discovery process. Stable cell (inheritable genotype) lines are chosen for their consistent profile and efficient measure of ...

Six vaccine candidates in clinical trials for COVID-19 employ viruses to deliver genetic cargo that, once inside our cells, instructs them to make SARS-CoV-2 protein. This stimulates an immune ...